A Population Based Strategy to Prevent Insulin-Dependent Diabetes Using Nicotinamide
@article{Elliott1996APB, title={A Population Based Strategy to Prevent Insulin-Dependent Diabetes Using Nicotinamide}, author={R. Elliott and C. Pilcher and D. Fergusson and A. Stewart}, journal={Journal of Pediatric Endocrinology and Metabolism}, year={1996}, volume={9}, pages={501 - 510} }
It has been postulated that treatment with nicotinamide may prevent or delay the onset of insulin dependent diabetes mellitus. We report the findings of a population based diabetes prevention trial which tests this hypothesis. 33,658 school children aged 5-7.9 years were randomly selected (by school) from a total population of 81,993 of such children in the Auckland (New Zealand) region. They were offered testing for islet cell antibodies. 20,195 (60%) consented to testing. Of these 185 had… CONTINUE READING
89 Citations
Effect of standard nicotinamide in the prevention of type 1 diabetes in first degree relatives of persons with type 1 diabetes
- Medicine
- Autoimmunity
- 2006
- 25
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes
- Medicine
- The Lancet
- 2004
- 444
- PDF
Update on Major Trials for the Prevention of Type I Diabetes Mellitus: The American Diabetes Prevention Trial (DPT-1) and the European Nicotinamide Diabetes Intervention Trial (ENDIT)
- Medicine
- Journal of pediatric endocrinology & metabolism : JPEM
- 2001
- 60
New therapeutic approaches to type 1 diabetes: from prevention to cellular or gene therapies
- Medicine
- Clinical endocrinology
- 2001
- 15
Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus.
- Biology, Medicine
- Advanced drug delivery reviews
- 1999
- 42
Prediabetes: prediction and prevention trials.
- Medicine
- Endocrinology and metabolism clinics of North America
- 2004
- 40
References
SHOWING 1-10 OF 21 REFERENCES
Early nicotinamide treatment in the NOD mouse: effects on diabetes and insulitis suppression and autoantibody levels.
- Medicine
- Diabetes research
- 1990
- 26
Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives.
- Medicine
- The Journal of clinical investigation
- 1994
- 86
- PDF
A universal model of antibody prediction (MAP) of type 1 diabetes in children.
- Medicine
- Journal of autoimmunity
- 1994
- 8
Competitive Insulin Autoantibody Assay: Prospective Evaluation of Subjects at High Risk for Development of Type I Diabetes Mellitus
- Medicine
- Diabetes
- 1987
- 200
Preventive and Therapeutic Effects of Large-Dose Nicotinamide Injections on Diabetes Associated with Insulitis: An Observation in Nonobese Diabetic (NOD) Mice
- Medicine
- Diabetes
- 1982
- 223
A sensitive and reproducible method for the assay of human islet cell antibodies.
- Medicine
- Journal of immunological methods
- 1990
- 42
Determination of glycosylated hemoglobin by affinity chromatography: comparison with colorimetric and ion-exchange methods, and effects of common interferences.
- Chemistry, Medicine
- Clinical chemistry
- 1982
- 237
- PDF
Automated and manual determination of N1-methylnicotinamide in urine.
- Medicine
- The American journal of clinical nutrition
- 1977
- 5
Planning for the appropriate analysis in school-based drug-use prevention studies.
- Psychology, Medicine
- Journal of consulting and clinical psychology
- 1990
- 234