A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria

@inproceedings{Riley2015APC,
  title={A Polyubiquitin Chain Reaction: Parkin Recruitment to Damaged Mitochondria},
  author={Brigit E. Riley and James A Olzmann},
  booktitle={PLoS genetics},
  year={2015}
}
Mutations in the E3 ubiquitin ligase Parkin or the mitochondrial kinase PINK1 cause autosomal recessive forms of Parkinson’s disease [1, 2]. Genetic and cell biological studies have implicated PINK1 and Parkin as critical elements in mitophagy, a mitochondrial quality control pathway that involves the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal system [1, 2]. Under basal conditions, PINK1 is processed by mitochondrial proteases and targeted for degradation by the UPS [1, 2… CONTINUE READING

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