A Polymorphism in the TNF-α Promoter Gene is Associated with Pediatric Onset and Colonic Location of Crohn's Disease

Abstract

OBJECTIVES:Studies suggest that pediatric onset of Crohn's disease (CD) may demonstrate more frequent upper intestinal and colonic location and in male gender, in comparison to adults. Variability in age of onset (AOO) and location of disease have not been adequately explained to date. NOD2/CARD15 is highly expressed in the ileum, while TNF-α expression is… (More)
DOI: 10.1111/j.1572-0241.2005.41126.x

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