A Polymorphism in the Regulatory Region of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants

@article{Kostrikis1999API,
  title={A Polymorphism in the Regulatory Region of the CC-Chemokine Receptor 5 Gene Influences Perinatal Transmission of Human Immunodeficiency Virus Type 1 to African-American Infants},
  author={L. Kostrikis and A. Neumann and B. Thomson and B. Korber and P. McHardy and R. Karanicolas and L. Deutsch and Y. Huang and J. Lew and K. Mcintosh and H. Pollack and W. Borkowsky and H. Spiegel and P. Palumbo and J. Oleske and A. Bardeguez and K. Luzuriaga and J. Sullivan and Steven Wolinsky and R. Koup and D. Ho and J. Moore},
  journal={Journal of Virology},
  year={1999},
  volume={73},
  pages={10264 - 10271}
}
ABSTRACT There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous for the CCR5-Δ32 allele, which prevents CCR5 expression, strongly resist HIV-1 infection. Several genetic polymorphisms have been identified within the CCR5 5′ regulatory region, some of which influence the rate of disease progression in adult AIDS study cohorts… Expand
CCR5 promoter polymorphisms in a Kenyan perinatal human immunodeficiency virus type 1 cohort: association with increased 2-year maternal mortality.
Effect of Genetic Variants of CCR2 and CCL2 on the Natural History of HIV-1 Infection: CCL2-2518GG Is Overrepresented in a Cohort of Spanish HIV-1-Infected Subjects
A haplotype in the CCR5 gene promoter was associated with the susceptibility to HIV-1 infection in a northern Chinese population
Polymorphism in the CCR5 gene promoter and HIV-1 infection in North Indians.
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