A Polymorphism in the PDLIM5 Gene Associated with Gene Expression and Schizophrenia

@article{Horiuchi2006API,
  title={A Polymorphism in the PDLIM5 Gene Associated with Gene Expression and Schizophrenia},
  author={Yasue Horiuchi and Makoto Arai and Kazuhiro Niizato and Shyuji Iritani and Tadao Arinami},
  journal={Biological Psychiatry},
  year={2006},
  volume={59},
  pages={434-439}
}
BACKGROUND Results of recent DNA microarray analyses of postmortem brains of patients with schizophrenia revealed that expression of the PDZ and LIM domain 5 gene (PDLIM5) is increased. In the present study, we examined whether polymorphisms in PDLIM5 are associated with schizophrenia. METHODS We screened for mutations in PDLIM5 in 24 Japanese patients with schizophrenia and evaluated the associations of the identified polymorphisms with schizophrenia in a Japanese case-control population… CONTINUE READING

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