A Polymorphism in the Macrophage Migration Inhibitory Factor Promoter Is Associated With Bronchopulmonary Dysplasia

@article{Prencipe2011API,
  title={A Polymorphism in the Macrophage Migration Inhibitory Factor Promoter Is Associated With Bronchopulmonary Dysplasia},
  author={Giusi Prencipe and Cinzia Auriti and Rita Inglese and Rita Devito and Maria Paola Ronchetti and Giulio Seganti and Lucilla Rav{\`a} and Marcello Orzalesi and Fabrizio de Benedetti},
  journal={Pediatric Research},
  year={2011},
  volume={69},
  pages={142-147}
}
Bronchopulmonary dysplasia (BPD) is a common adverse outcome of prematurity, causing severe morbidity and mortality. The cytokine macrophage migration inhibitory factor (MIF) has been recently shown to favor murine fetal lung development. In this prospective study, we evaluate the expression of MIF in the lung and in the serum of preterm infants (n = 50) and investigate whether the −173 G/C MIF promoter polymorphism is associated with the risk of BPD (n = 103). MIF was highly expressed in lung… CONTINUE READING
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Antenatal inflammation and lung injury: prenatal origin of neonatal disease

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