A Polymorphism in Human MR1 is Associated with mRNA Expression and Susceptibility to Tuberculosis

@inproceedings{Seshadri2017API,
  title={A Polymorphism in Human MR1 is Associated with mRNA Expression and Susceptibility to Tuberculosis},
  author={Chetan Seshadri and Nguyen Thuy Thuong Thuong and Nguyen Thi Hoan Mai and Nguyen Duc Bang and Tran Thi Hong Chau and D M Lewinsohn and Guy E Thwaites and Sarah J Dunstan and Thomas Richard Hawn},
  booktitle={Genes and Immunity},
  year={2017}
}
The MR1 antigen-presenting system is conserved among mammals and enables T cells to recognize small molecules produced by bacterial pathogens, including Mycobacterium tuberculosis (M.tb). However, it is not known whether MR1-mediated antigen presentation is important for protective immunity against mycobacterial disease. We hypothesized that genetic control of MR1 expression correlates with clinical outcomes of tuberculosis infection. We performed an MR1 candidate gene association study and… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 40 references

Integrative analysis of 111 reference human epigenomes

Consortium Roadmap Epigenomics, A Kundaje, +3 authors A Yen
Nature • 2015

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