A Polymorphism at the 3′-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma

@inproceedings{Liu2013APA,
  title={A Polymorphism at the 3′-UTR Region of the Aromatase Gene Is Associated with the Efficacy of the Aromatase Inhibitor, Anastrozole, in Metastatic Breast Carcinoma},
  author={Lei Liu and Yu-xian Bai and Jianhua Zhou and Xiu-Wei Sun and Hong Sui and Wen-jie Zhang and Heng-heng Yuan and Rui Zheng Xie and Xiao-Li Wei and Ting-ting Zhang and Peng Huang and Yan-jing Li and Jing-xuan Wang and Shu Wei Zhao and Qingyuan Zhang},
  booktitle={International journal of molecular sciences},
  year={2013}
}
Estrogen-related genes and the fat mass and obesity-associated (FTO) gene play a critical role in estrogen metabolism, and those polymorphisms are associated with a poor prognosis in breast cancer. However, little is known about the association between these polymorphisms and the efficacy of anastrozole. The aim was to investigate the impact of the genetic polymorphisms, CYP19A1, 17-β-HSD-1 and FTO, on the response to anastrozole in metastatic breast carcinoma (MBC) and to evaluate the impact… CONTINUE READING

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