A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection

@article{ZeronMedina2013APP,
  title={A Polymorphic p53 Response Element in KIT Ligand Influences Cancer Risk and Has Undergone Natural Selection},
  author={Jorge Zeron-Medina and Xuting Wang and Emmanouela Repapi and Michelle R. Campbell and Dan Su and Francesc Castro-Giner and Benjamin D Davies and Elisabeth F P Peterse and Natalia Sacilotto and Graeme J. Walker and Tamara Terzian and Ian P. M. Tomlinson and Neil F. Box and Nicolai Meinshausen and Sarah J. De Val and Douglas A. Bell and Gareth L. Bond},
  journal={Cell},
  year={2013},
  volume={155},
  pages={410-422}
}
The ability of p53 to regulate transcription is crucial for tumor suppression and implies that inherited polymorphisms in functional p53-binding sites could influence cancer. Here, we identify a polymorphic p53 responsive element and demonstrate its influence on cancer risk using genome-wide data sets of cancer susceptibility loci, genetic variation, p53 occupancy, and p53-binding sites. We uncover a single-nucleotide polymorphism (SNP) in a functional p53-binding site and establish its… CONTINUE READING
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