A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding

@inproceedings{Lewis2014APE,
  title={A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding},
  author={Annabelle Lewis and Luke Freeman-Mills and Elisa de la Calle-Mustienes and Rosa M Gir{\'a}ldez-P{\'e}rez and Hayley G. Davis and Emma E M Jaeger and Martin Becker and Nina C. Hubner and Luan N Nguyen and Jorge Zeron-Medina and Gareth L. Bond and Hendrik G. Stunnenberg and Jaime J. Carvajal and Jos{\'e} Luis G{\'o}mez-Skarmeta and Simon John Leedham and Ian P. M. Tomlinson},
  booktitle={Cell reports},
  year={2014}
}
A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal epithelium. Here, we confirm that a common GREM1 polymorphism, rs16969681, is also associated with CRC susceptibility, conferring ∼20% differential risk in the general population. We hypothesized the underlying cause to be moderate differences in… CONTINUE READING

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