A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery

@inproceedings{Xie2013APA,
  title={A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery},
  author={Jing Xie and Lesheng Teng and Zhaogang Yang and Chenguang Zhou and Yang Liu and Bryant C Yung and Robert J Lee},
  booktitle={BioMed research international},
  year={2013}
}
A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PEI (Mw ~ 800) with linoleoyl chloride. Gel retardation assay showed complete complexation between PEI-LA and LOR-2501 at N/P ratio above 8. No significant cytotoxicity was observed with these… CONTINUE READING
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