A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.

Abstract

BACKGROUND & AIMS Genome-wide association studies have identified 200 inflammatory bowel disease (IBD) loci, but the genetic architecture of Crohn's disease (CD) and ulcerative colitis remain incompletely defined. Here, we aimed to identify novel associations between IBD and functional genetic variants using the Illumina ExomeChip (San Diego, CA). METHODS… (More)
DOI: 10.1053/j.gastro.2016.06.051

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@article{Li2016APM, title={A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.}, author={Dalin Li and J. P. Achkar and Talin Haritunians and Jonathan P Jacobs and Ken Yon Hui and Mauro D'Amato and Stephan Brand and Graham L. Radford-Smith and Jonas Halfvarson and J Niess and Subra Kugathasan and Carsten Buening and Ludwig Philip Schumm and Lambertus L Klei and Ashwin N. Ananthakrishnan and Guy Aumais and Leonard Baidoo and Marla Cindy Dubinsky and Claudio Fiocchi and J{\"{u}rgen Glas and Raquel Milgrom and D. D. Proctor and Miguel D. Regueiro and Lisa A. Simms and Joanne M Stempak and Stephan Raoul Targan and Leif T{\"{o}rkvist and Yashoda Sharma and Bernie J Devlin and James Borneman and Hakon Hakonarson and Ramnik J. Xavier and Mark Daly and Steven R. Brant and John David Rioux and Mark S. Silverberg and Judy H. Cho and Jonathan Braun and Dermot P. B. McGovern and Richard H. Duerr}, journal={Gastroenterology}, year={2016}, volume={151 4}, pages={724-32} }