A Plasmodium falciparum copper-binding membrane protein with copper transport motifs

@inproceedings{Choveaux2012APF,
  title={A Plasmodium falciparum copper-binding membrane protein with copper transport motifs},
  author={David L Choveaux and Jude M Przyborski and J P Dean Goldring},
  booktitle={Malaria Journal},
  year={2012}
}
Copper is an essential catalytic co-factor for metabolically important cellular enzymes, such as cytochrome-c oxidase. Eukaryotic cells acquire copper through a copper transport protein and distribute intracellular copper using molecular chaperones. The copper chelator, neocuproine, inhibits Plasmodium falciparum ring-to-trophozoite transition in vitro, indicating a copper requirement for malaria parasite development. How the malaria parasite acquires or secretes copper still remains to be… CONTINUE READING