A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface

@inproceedings{Oberli2014APF,
  title={A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface},
  author={Alexander Oberli and Leanne M. Slater and Erin E. Cutts and Françoise Brand and Esther Mundwiler-Pachlatko and Sebastian Rusch and Martin F. G. Masik and Mich{\`e}le C. Erat and Hans-Peter Beck and Ioannis Vakonakis},
  booktitle={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2014}
}
Uniquely among malaria parasites, Plasmodium falciparum-infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane protein 1 (PfEMP1) clusters. Knob formation and the associated iRBC adherence to host endothelium are directly linked to the severity of malaria and are functional manifestations of protein export from the parasite to the iRBC. A family of exported proteins featuring Plasmodium helical… CONTINUE READING
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