A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria.

  title={A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria.},
  author={Tiffany Sun and Thomas Holowka and Yan Song and Swen Zierow and Lin Leng and Yibang Chen and Huabao Xiong and Jason Griffith and Mehdi S Nouraie and Philip E Thuma and Elias Lolis and Chris J Janse and Victor R Gordeuk and Kevin D. Augustijn and Richard Bucala},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 31},
The inability to acquire protective immunity against Plasmodia is the chief obstacle to malaria control, and inadequate T-cell responses may facilitate persistent blood-stage infection. Malaria is characterized by a highly inflammatory cytokine milieu, and the lack of effective protection against infection suggests that memory T cells are not adequately formed or maintained. Using a genetically targeted strain of Plasmodium berghei, we observed that the Plasmodium ortholog of macrophage… CONTINUE READING
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