A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomers.

@article{Schler2005APA,
  title={A Plasmodium actin-depolymerizing factor that binds exclusively to actin monomers.},
  author={Herwig Sch{\"u}ler and A Mueller and Kai Matuschewski},
  journal={Molecular biology of the cell},
  year={2005},
  volume={16 9},
  pages={
          4013-23
        }
}
ADF/cofilins (AC) are essential F- and G-actin binding proteins that modulate microfilament turnover. The genome of Plasmodium falciparum, the parasite causing malaria, contains two members of the AC family. Interestingly, P. falciparum ADF1 lacks the F-actin binding residues of the AC consensus. Reverse genetics in the rodent malaria model system suggest that ADF1 performs vital functions during the pathogenic red blood cell stages, whereas ADF2 is not present in these stages. We show that… CONTINUE READING

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