A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation

@article{Aviezer2009APR,
  title={A Plant-Derived Recombinant Human Glucocerebrosidase Enzyme—A Preclinical and Phase I Investigation},
  author={David Aviezer and Einat Brill-Almon and Yoseph Shaaltiel and Sharon Hashmueli and Daniel Bartfeld and Sarah Mizrachi and Yael Liberman and Arnold Freeman and Ari Zimran and Eithan Galun},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={1464 - 1470}
}
UNLABELLED Gaucher disease is a progressive lysosomal storage disorder caused by the deficiency of glucocerebrosidase leading to the dysfunction in multiple organ systems. Intravenous enzyme replacement is the accepted standard of treatment. In the current report, we evaluate the safety and pharmacokinetics of a novel human recombinant glucocerebrosidase enzyme expressed in transformed plant cells (prGCD), administered to primates and human subjects. Short term (28 days) and long term (9 months… CONTINUE READING
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