A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression

@article{Abramovitch2004APR,
  title={A Pivotal Role of Cyclic AMP-Responsive Element Binding Protein in Tumor Progression},
  author={R. Abramovitch and E. Tavor and J. Jacob-Hirsch and E. Zeira and N. Amariglio and O. Pappo and G. Rechavi and E. Galun and A. Honigman},
  journal={Cancer Research},
  year={2004},
  volume={64},
  pages={1338 - 1346}
}
Tumor microenvironment controls the selection of malignant cells capable of surviving in stressful and hypoxic conditions. The transcription factor, cyclic AMP-responsive element binding (CREB) protein, activated by multiple extracellular signals, modulates cellular response by regulating the expression of a multitude of genes. Previously, we have demonstrated that two cystein residues, at the DNA binding domain of CREB, mediate activation of CREB-dependent gene expression at normoxia and… Expand
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