A Pilot Study of Mifepristone in Combat-Related PTSD

@inproceedings{Golier2012APS,
  title={A Pilot Study of Mifepristone in Combat-Related PTSD},
  author={Julia A. Golier and Kimberly Caramanica and Rebecca DeMaria and Rachel Yehuda},
  booktitle={Depression research and treatment},
  year={2012}
}
Background. We obtained pilot data to examine the clinical and neuroendocrine effects of short-term mifepristone treatment in male veterans with PTSD. Methods. Eight male veterans with military-related PTSD completed a randomized, double-blind trial of one week of treatment with mifepristone (600 mg/day) or placebo. The primary clinical outcome measures were improvement in PTSD symptoms and dichotomously defined clinical responder status as measured by the CAPS at one-month follow-up… CONTINUE READING

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Glucocorticoid receptor antagonist C-1073 (mifepristone/RU486) inhibits P-glycoprotein-mediated efflux transport of cortisol

  • A. M. Karssen, J. K. Belanoff, E. R. de Kloet
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