A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

@inproceedings{McCarthy2011APR,
  title={A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs},
  author={James S McCarthy and Silvana Sekuloski and Paul Matthew Griffin and Suzanne Elliott and Nanette Douglas and Christopher L. Peatey and Rebecca J. Rockett and P K O'rourke and Louise Marquart and Cornelius C Hermsen and Stephan Duparc and Joerg J Moehrle and Katharine Trenholme and Andrew J. Humberstone},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND Critical to the development of new drugs for treatment of malaria is the capacity to safely evaluate their activity in human subjects. The approach that has been most commonly used is testing in subjects with natural malaria infection, a methodology that may expose symptomatic subjects to the risk of ineffective treatment. Here we describe the development and pilot testing of a system to undertake experimental infection using blood stage Plasmodium falciparum parasites (BSP). The… CONTINUE READING

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Assessment of the pharmacodynamic properties of antimalarial drugs in vivo

  • NJ White
  • Antimicrob Agents Chemother
  • 1997
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