A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children

@article{Ogungbenro2014APB,
  title={A Physiologically Based Pharmacokinetic Model for Clobazam and Stiripentol in Adults and Children},
  author={Kayode Ogungbenro and Leon Aarons},
  journal={Pharmaceutical Research},
  year={2014},
  volume={32},
  pages={144-157}
}
To develop a physiologically based pharmacokinetic model in adults and children for clobazam, its active metabolite norclobazam and stiripentol and to account for significant clinical interaction that has been reported when clobazam and stiripentol are co-administered. A PBPK model with ten compartments was developed. An in vitro-in vivo extrapolation technique was used to scale clearance in children for clobazam and norclobazam and clearance parameters for stiripentol were obtained from… CONTINUE READING
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