A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior

@article{vomSaal1998APB,
  title={A Physiologically Based Approach To the Study of Bisphenol a and Other Estrogenic Chemicals On the Size of Reproductive Organs, Daily Sperm Production, and Behavior},
  author={Frederick S vom Saal and Paul S. Cooke and David L. Buchanan and Paola Palanza and Kristina A Thayer and Susan C. Nagel and Stefano Parmigiani and Wade V. Welshons},
  journal={Toxicology and Industrial Health},
  year={1998},
  volume={14},
  pages={239 - 260}
}
Two chemicals previously shown to have estrogenic activity, bisphenol A and octylphenol, were examined for their effects on accessory reproductive organs and daily sperm production in male offspring of mice fed these chemicals during pregnancy. These chemicals are used in the manufacture of plastics and other products, and have been detected in food and water consumed by animals and people. From gestation day 11-17 female mice were fed an average concentration (dissolved in oil) of bisphenol A… 

Figures and Tables from this paper

Metabolism and disposition of bisphenol A in female rats.
TLDR
Radioactivity in pup carcasses indicated exposure in the range of microgram equivalents per kilogram; those values ranged from 44.3 +/- 24.4 for pups separated from their lactating dams at 2 h to 78.4 +/- 10.9 at 24 h, indicating that metabolism via glucuronidation is a detoxication reaction.
EVALUATION TOXIC EFFECT OF BISPHENOL A IN REPRODUCTIVE SYSTEM OF MALE MICE AND AMELIORATION ITS EFFECT BY GREEN TEA EXTRACT
Bisphenol A (BPA) is a chemical compound have chemical formula (CH3)2C(C6H4OH)2. Bisphenol A (BPA) is use to synthesis various plastic and epoxy resin such as water bottle, many food and beverage
In vivo analysis of bisphenol A-induced sub-chronic toxicity on reproductive accessory glands of male mice and its amelioration by quercetin
TLDR
According to studies, even at very low doses, BPA mimic estrogen resulting in an array of health maladies including prostate cancer as well as breast cancers, genotoxic effect (Karim and Husain, 2010) and other health problems.
Adverse effects of environmental toxicants, octylphenol and bisphenol A, on male reproductive functions in pubertal rats
TLDR
It is demonstrated that OP and BPA can reduce sperm counts resulting from lowered plasma testosterone in male rats just after puberty, raising the possibility of a link between these chemicals and prostate diseases because IGF-I has been implicated in the pathogenesis of human prostate cancers.
Dietary exposure to low doses of bisphenol A: Effects on reproduction and development in two generations of C57BL/6J mice
TLDR
Findings indicate that dietary exposure to bisphenol A between 0.33 and 33 ppm does not adversely affect reproduction or development as assessed in two generations of mice.
Long-Term Effects of Fetal Exposure to Low Doses of the Xenoestrogen Bisphenol-A in the Female Mouse Genital Tract1
TLDR
In utero exposure to low, environmentally relevant doses of BPA induces alterations in the genital tract of female offspring that are revealed during adulthood, and it is plausible that BPA may directly affect the expression of ER-controlled genes involved in the morphogenesis of these organs.
Reproductive Malformation of The Male Offspring Following Maternal Exposure To Estrogenic Chemicals (44516)
  • C. Gupta
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 2000
TLDR
This is the first demonstration that estrogenic chemicals induce reproductive malformation by direct interference with the fetal reproductive organs and not by interfering with the maternal or fetal endocrine system.
...
...

References

SHOWING 1-10 OF 87 REFERENCES
Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production.
TLDR
Exposure of male rats to two estrogenic, environmental chemicals during gestation or during the first 21 days of postnatal life, affected testicular size or spermatogenesis in adulthood, and none of the treatments had any adverse effect on testicular morphology or on the cross-sectional area of the lumen or seminiferous epithelium.
Environmentally persistent alkylphenolic compounds are estrogenic.
TLDR
It is shown that a number of alkylphenolic compounds, used in a variety of commercial products and found in river water, are estrogenic in fish, birds, and mammals and capable of stimulating vitellogenin gene expression in trout hepatocytes, gene transcription in transfected cells, and the growth of breast cancer cell lines.
The developmental toxicity of bisphenol A in rats and mice.
The environmental estrogen bisphenol A stimulates prolactin release in vitro and in vivo.
TLDR
BPA mimics estradiol in inducing hyperprolactinemia in genetically predisposed rats and the in vivo action is mediated, at least in part, by increasing PRL regulating factor activity in the posterior pituitary.
Development of a marker of estrogenic exposure in human serum.
TLDR
The ongoing development of a method to extract and separate xenoestrogens from ovarian estrogens with human serum as a source is reported, followed by determination ofxenoestrogen concentration by a bioassay, which critically assess bioassays currently available to measure the cumulative effect of xenoESTrogens.
Intrauterine position effects on steroid metabolism and steroid receptors of reproductive organs in male mice.
TLDR
It is suggested that intrauterine fetal position exerts a significant influence on subsequent adult androgen metabolism and androgen responsiveness in reproductive organs of adult male mice.
Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving.
TLDR
The findings raise the possibility that unsuspected estrogenic activity in the form of BPA may have an impact on experiments employing media autoclaved in polycarbonate flasks, and it remains to be determined whether BPA derived from consumer products manufactured from poly carbonate could significantly contribute to the pool of estrogenic substances in the environment.
Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals
TLDR
Exposure of male rainbow trout to four different alkylphenolic chemicals caused synthesis of vitellogenin, a process normally dependent on endogenous estrogens, and a concomitant inhibition of testicular growth, support the contention that exposure of wildlife to environmentally persistent estrogenic chemicals can result in deleterious reproductive consequences.
Xenoestrogens released from lacquer coatings in food cans.
TLDR
It is apparent that all estrogenic activity in these cans was due to bisphenol-A leached from the lacquer coating, and the use of plastic in food-packaging materials may require closer scrutiny to determine whether epoxy resins and polycarbonates contribute to human exposure to xenoestrogens.
...
...