A Photorearrangement To Construct the ABDE Tetracyclic Core of Palau'amine.

Abstract

A synthesis of the ABDE tetracyclic carbon core of palau'amine was achieved in 9 steps from commercial materials. The core's most notable feature, a highly strained trans cyclopenta[ c]pyrrolidine, was obtained in high yield using a ring contraction strategy starting from a much less strained trans bicyclic lactam derivative that is accessible in only 7… (More)
DOI: 10.1021/acs.orglett.8b00819

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