A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.

@article{Zhang2006AP3,
  title={A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression.},
  author={Qin Zhang and Pavan Adiseshaiah and Dhananjaya V. Kalvakolanu and Sekhar P. M. Reddy},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 15},
  pages={10174-81}
}
The FRA-1 proto-oncogene is overexpressed in a variety of human tumors and is known to up-regulate the expression of genes involved in tumor progression and invasion. The phosphatidylinositol 3-kinase (PI3K)-Akt pathway is also known to regulate these cellular processes. More importantly, respiratory toxicants and carcinogens activate both the PI3K-Akt pathway and FRA-1 expression in human bronchial epithelial (HBE) cells. In this study we investigated a potential link between the PI3K-Akt… CONTINUE READING