A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release

  title={A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release},
  author={Tao Wang and Luping Yin and Xiaolong Zou and Yousheng Shu and M. Rasch and Si Wu},
  journal={Frontiers in Computational Neuroscience},
  • Tao Wang, Luping Yin, +3 authors Si Wu
  • Published 2016
  • Computer Science, Medicine
  • Frontiers in Computational Neuroscience
Neurons communicate with each other via synapses. Action potentials cause release of neurotransmitters at the axon terminal. Typically, this neurotransmitter release is tightly time-locked to the arrival of an action potential and is thus called synchronous release. However, neurotransmitter release is stochastic and the rate of release of small quanta of neurotransmitters can be considerably elevated even long after the ceasing of spiking activity, leading to asynchronous release of… Expand
2 Citations
The Effect of pH on Synaptic Transmission at the Neuromuscular Junction in Drosophila melanogaster
Background and Objective: The effects of intracellular and extracellular pH changes on synaptic transmission have been studied for many years in different models. Intracellular acidification at theExpand
Identifiability of a Binomial Synapse
A formal definition for the practical identifiability domain of a statistical model, which corresponds to the set of parameters for which the model is correctly identified as the ground truth compared to a simpler alternative model is proposed and applied to the study of neurotransmitter release at a chemical synapse. Expand


Asynchronous Transmitter Release from Cholecystokinin-Containing Inhibitory Interneurons Is Widespread and Target-Cell Independent
It is shown that three classes of depolarization-induced suppression of inhibition-expressing, cholecystokinin (CCK)-containing, hippocampal interneurons show highly asynchronous release in response to trains of action potentials, indicating a fundamental role for these cells within the hippocampal network that is distinct from the phasic inhibition provided by parvalbumin-containing interneuron. Expand
Competition between Phasic and Asynchronous Release for Recovered Synaptic Vesicles at Developing Hippocampal Autaptic Synapses
Despite depression of phasic release during train stimulation, transmission can be maintained at a near-maximal rate by switching to an asynchronous mode that takes advantage of a bulk presynaptic [Ca2+]i. Expand
Two components of transmitter release at a central synapse.
  • Y. Goda, C. Stevens
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1994
The findings are comparable to those of the classical studies for the frog neuromuscular junction, and thus the basic aspects of Ca(2+)-activated transmitter release machinery appear to be conserved in central synapses. Expand
Modelling Vesicular Release at Hippocampal Synapses
These detailed Monte Carlo simulations allow us to identify features of synaptic transmission that are universal and those that are modulated by structure and reveal a third time scale of vesicle release that is correlated with the stimulus and is distinct from the fast and the slow releases. Expand
Short-term synaptic plasticity.
The evidence for this hypothesis, and the origins of the different kinetic phases of synaptic enhancement, as well as the interpretation of statistical changes in transmitter release and roles played by other factors such as alterations in presynaptic Ca(2+) influx or postsynaptic levels of [Ca(2+)]i are discussed. Expand
The mechanisms and functions of spontaneous neurotransmitter release
  • E. Kavalali
  • Chemistry, Medicine
  • Nature Reviews Neuroscience
  • 2014
Findings indicate that spontaneous neurotransmission has an autonomous role in interneuronal communication that is distinct from that of evoked release, challenging current assumptions about neuronal signalling and neurotransmission. Expand
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron–principal neuron synapse
It is shown that cholecystokinin (CCK)-expressing interneurons in rat dentate gyrus release GABA in a highly asynchronous manner, in contrast to parvalbumin (PV) interneurs, thus generating long-lasting inhibition in the brain. Expand
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
The results reveal that release triggered in wild-type synapses at low Ca2+ concentrations is physiologically asynchronous, and that asynchronous release completely empties the readily releasable pool of vesicles during sustained elevations of Ca2+. Expand
Developmental reduction of asynchronous GABA release from neocortical fast-spiking neurons.
Recording from fast-spiking interneurons and pyramidal cells in prefrontal cortical slices obtained from juvenile and adult rats revealed that the AR strength was stronger at juvenile but weaker in adult, possibly resulting from changes in presynaptic Ca(2+) dynamics. Expand
A General Model of Synaptic Transmission and Short-Term Plasticity
This work offers a comprehensive model of presynaptic processes, encompassing mobilization of reserve vesicles, priming of docked vesicle, their association with Ca(2+) channels, and refractoriness of release sites, while accounting for data on presYNaptic buffers governing Ca( 2+) diffusion. Expand