A Phase II Clinical Trial of Flutamide in the Treatment of Advanced Breast Cancer

@article{Zhao1988API,
  title={A Phase II Clinical Trial of Flutamide in the Treatment of Advanced Breast Cancer},
  author={Tiping Zhao and G F He},
  journal={Tumori Journal},
  year={1988},
  volume={74},
  pages={53 - 56}
}
  • T. Zhao, G. He
  • Published 1 February 1988
  • Medicine, Biology
  • Tumori Journal
An antiandrogenic agent flutamide was used in the treatment of one male and 14 female postmenopausal breast cancer patients. Only a mild and transient response was seen in 2 female patients. Therefore, flutamide cannot be used solely in the treatment of female postmenopausal breast cancer. 
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Selective androgen receptor modulators as improved androgen therapy for advanced breast cancer
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Growth inhibition of DMBA-induced rat mammary carcinomas by the antiandrogen flutamide
TLDR
It is demonstrated that the antiandrogen FLU and the full androgen DHT exert similar inhibitory effects on the growth of dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, and data show that plasma steroids levels are unaffected by FLU treatment.
Role of the androgen receptor in triple-negative breast cancer.
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Despite lower pathologic complete response (pCR) rates with neoadjuvant therapy, patients with AR-dependent TNBCs have a better prognosis than those with T NBCs that are not AR- dependent, and this paper describes the results of early clinical trials with antiandrogens in this population.
Inhibitory effect of hydroxyflutamide plus tamoxifen on oestradiol-induced growth of MCF-7 breast cancer cells
TLDR
The antiproliferative effect of hydroxyflutamide, without virilizing side-effects, suggests that it is worth exploring its possible employment together with antioestrogens in the treatment of breast cancer patients.
The Role of Androgen Receptor in Breast Cancer.
Androgen receptor expression in breast cancer: Implications on prognosis and treatment, a brief review
The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
TLDR
Understanding of the role of the AR in BCa progression is further understood and it is suggested that it is a valid therapeutic target to prevent and/or treat endocrine resistant disease.
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