A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy

@article{Hiki2011API,
  title={A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy},
  author={N. Hiki and M. Kaminishi and T. Hasunuma and M. Nakamura and S. Nomura and N. Yahagi and H. Tajiri and H. Suzuki},
  journal={Clinical Pharmacology & Therapeutics},
  year={2011},
  volume={90}
}
  • N. Hiki, M. Kaminishi, +5 authors H. Suzuki
  • Published 2011
  • Chemistry, Medicine
  • Clinical Pharmacology & Therapeutics
  • Peppermint oil has been shown to relax gastrointestinal smooth muscle. In this randomized, placebo‐controlled study, an L‐menthol preparation, NPO‐11, was assessed for tolerability and pharmacokinetics (PK) during gastrointestinal endoscopy. Single doses of NPO‐11, as high as 320 mg, were well tolerated. NPO‐11 was rapidly absorbed, with peak concentrations reached within 1 h after administration. Approximately 70% of the administered L‐menthol and its metabolites were excreted in the urine… CONTINUE READING
    Menthol Smokers: Metabolomic Profiling and Smoking Behavior
    • 7
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 31 REFERENCES
    Case report.
    • 6,034
    Menthol and Related Cooling Compounds
    • 387
    Metabolic fate of [3H]-l-menthol in the rat.
    • 47