A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy

@article{Hiki2011API,
  title={A Phase I Study Evaluating Tolerability, Pharmacokinetics, and Preliminary Efficacy of L‐Menthol in Upper Gastrointestinal Endoscopy},
  author={Naoki Hiki and Michio Kaminishi and Tomoko Hasunuma and M. Nakamura and Sachiyo Nomura and Naohisa Yahagi and Hisao Tajiri and H. Suzuki},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2011},
  volume={90}
}
Peppermint oil has been shown to relax gastrointestinal smooth muscle. In this randomized, placebo‐controlled study, an L‐menthol preparation, NPO‐11, was assessed for tolerability and pharmacokinetics (PK) during gastrointestinal endoscopy. Single doses of NPO‐11, as high as 320 mg, were well tolerated. NPO‐11 was rapidly absorbed, with peak concentrations reached within 1 h after administration. Approximately 70% of the administered L‐menthol and its metabolites were excreted in the urine… 

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