A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

@inproceedings{Springett2015API,
  title={A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia},
  author={Gregory M. Springett and Kazim Husain and Anthony M Neuger and Barbara Ann Centeno and Dung-Tsa Chen and Tai Hutchinson and Richard M. Lush and Sa{\"i}d M. Sebti and Mokenge Peter Malafa},
  booktitle={EBioMedicine},
  year={2015}
}
BACKGROUND Vitamin E δ-tocotrienol (VEDT), a natural vitamin E from plants, has shown anti-neoplastic and chemoprevention activity in preclinical models of pancreatic cancer. Here, we investigated VEDT in patients with pancreatic ductal neoplasia in a window-of-opportunity preoperative clinical trial to assess its safety, tolerability, pharmacokinetics, and apoptotic activity. METHODS Patients received oral VEDT at escalating doses (from 200 to 3200 mg) daily for 13 days before surgery and… CONTINUE READING

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