A Pharmacokinetic Study of Intravenous CTLA4Ig, a Novel Immunosuppressive Agent, in Mice

  title={A Pharmacokinetic Study of Intravenous CTLA4Ig, a Novel Immunosuppressive Agent, in Mice},
  author={N. Srinivas and R. Weiner and W. Shyu and J. Calore and D. Tritschler and L. Tay and J. Lee and D. Greene and R. Barbhaiya},
  journal={Journal of Pharmaceutical Sciences},
Abstract Three skin-intact mice in each group received a single 0.07-, 0.29-, or 0.57-mg dose of CTLA4Ig intravenously (iv). Three skin-grafted mice received a single 0.29-mg dose iv and another three skin-grafted mice received a 0.29-mg dose once daily for 7 days (the dose was administered via the tail vein). Serial blood samples (0.15 mL) were obtained by retro-orbital bleeds up to 240 h after all single doses and up to 360 h after the last multiple dose. Serum samples were analyzed for… Expand
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