A Pharmacokinetic Analysis of Long‐Term Administration of Rubidium Chloride

  title={A Pharmacokinetic Analysis of Long‐Term Administration of Rubidium Chloride},
  author={Herbert L. Meltzer},
  journal={The Journal of Clinical Pharmacology},
  • H. Meltzer
  • Published 1 February 1991
  • Biology
  • The Journal of Clinical Pharmacology
When a substance with a long biologic half‐life is administered over an extended period with a varying dose schedule, many concerns about safety arise. In the case of rubidium chloride, which has been reported to have antidepressive activity, some of these concerns are related to the potential for unanticipated accumulation in the intracellular fluid, where replacement of more than 40% of the potassium ion is associated with toxicity in animals. A pharmacokinetic model of rubidium distribution… 

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