A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies

@inproceedings{Wiegand2017APH,
  title={A Persistent Hotspot of Schistosoma mansoni Infection in a Five-Year Randomized Trial of Praziquantel Preventative Chemotherapy Strategies},
  author={Ryan E. Wiegand and Pauline N. M. Mwinzi and Susan P. Montgomery and Yi Lok Chan and Kennedy Andiego and Martin O Omedo and Geoffrey Muketha Muchiri and Michael O Ogutu and Fredrick O. Rawago and Maurice Reuben Odiere and Diana M. S. Karanja and W Evan Secor},
  booktitle={The Journal of infectious diseases},
  year={2017}
}
Background Persistent hotspots have been described after mass drug administration (MDA) for the control of schistosomiasis, but they have not been studied during the course of a multiyear MDA program. Methods In data from a 5-year study of school-based and village-wide preventive chemotherapy strategies for Schistosoma mansoni, spatial scan statistics were used to find infection hotspots in 3 populations: 5- to 8-year-olds, 9- to 12-year-olds, and adults. Negative binomial regression was used… CONTINUE READING
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