A Persistent Cellular Change in a Single Modulatory Neuron Contributes to Associative Long-Term Memory

@article{Jones2003APC,
  title={A Persistent Cellular Change in a Single Modulatory Neuron Contributes to Associative Long-Term Memory},
  author={Nicholas G. Jones and Ildiko Kemenes and Gy{\"o}rgy Kemenes and Paul R. Benjamin},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={1064-1069}
}
Most neuronal models of learning assume that changes in synaptic strength are the main mechanism underlying long-term memory (LTM) formation. However, we show here that a persistent depolarization of membrane potential, a type of cellular change that increases neuronal responsiveness, contributes significantly to a long-lasting associative memory trace. The use of a model invertebrate network with identified neurons and known synaptic connectivity had the advantage that the contribution of this… CONTINUE READING
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