A Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription

@article{Kraetzner2008APP,
  title={A Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription},
  author={R. Kraetzner and F. Fr{\"o}hlich and Katrin Lepler and M. Schr{\"o}der and K. Roeher and C. Dickel and M. Tzvetkov and T. Quentin and E. Oetjen and W. Knepel},
  journal={Molecular Pharmacology},
  year={2008},
  volume={73},
  pages={509 - 517}
}
  • R. Kraetzner, F. Fröhlich, +7 authors W. Knepel
  • Published 2008
  • Biology, Medicine
  • Molecular Pharmacology
  • The peptide hormone glucagon stimulates hepatic glucose output, and its levels in the blood are elevated in type 2 diabetes mellitus. The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has essential roles in glucose homeostasis, and thiazolidinedione PPARγ agonists are clinically important antidiabetic drugs. As part of their antidiabetic effect, thiazolidinediones such as rosiglitazone have been shown to inhibit glucagon gene transcription through binding to PPARγ and… CONTINUE READING
    18 Citations
    PPARβ/δ activation induces enteroendocrine L cell GLP-1 production.
    • 44
    • PDF
    Inhibiting or antagonizing glucagon: making progress in diabetes care
    • 28

    References

    SHOWING 1-10 OF 51 REFERENCES
    Repression of Glucagon Gene Transcription by Peroxisome Proliferator-activated Receptor γ through Inhibition of Pax6 Transcriptional Activity*
    • 29
    • Highly Influential
    • PDF
    The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • 3,533
    Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells.
    • 33
    Peroxisomal Proliferator-Activated Receptor-γ Upregulates Glucokinase Gene Expression in β-Cells
    • 83
    • PDF
    Expression of peroxisome proliferator-activated receptor gamma (PPARgamma) in normal human pancreatic islet cells.
    • 68
    • Highly Influential
    Expression of peroxisome proliferator-activated receptor γ (PPARγ) in normal human pancreatic islet cells
    • 123
    • PDF