A Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription

@article{Kraetzner2008APP,
  title={A Peroxisome Proliferator-Activated Receptor γ-Retinoid X Receptor Heterodimer Physically Interacts with the Transcriptional Activator PAX6 to Inhibit Glucagon Gene Transcription},
  author={R. Kraetzner and F. Fr{\"o}hlich and Katrin Lepler and M. Schr{\"o}der and K. Roeher and C. Dickel and M. Tzvetkov and T. Quentin and E. Oetjen and W. Knepel},
  journal={Molecular Pharmacology},
  year={2008},
  volume={73},
  pages={509 - 517}
}
  • R. Kraetzner, F. Fröhlich, +7 authors W. Knepel
  • Published 2008
  • Biology, Medicine
  • Molecular Pharmacology
    • The peptide hormone glucagon stimulates hepatic glucose output, and its levels in the blood are elevated in type 2 diabetes mellitus. The nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) has essential roles in glucose homeostasis, and thiazolidinedione PPARγ agonists are clinically important antidiabetic drugs. As part of their antidiabetic effect, thiazolidinediones such as rosiglitazone have been shown to inhibit glucagon gene transcription through binding to PPARγ and… CONTINUE READING
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    18 Citations
    Background Citations
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    Methods Citations
    1
    Results Citations
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    18 Citations
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    Citation Type

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    Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC.
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