A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

@article{Brandhorst2015APD,
  title={A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.},
  author={Sebastian Brandhorst and In Young Choi and Min Wei and Chia Wei Cheng and Sargis Sedrakyan and Gerardo S Navarrete and Louis Dubeau and Li Peng Yap and Ryan Park and Manlio Vinciguerra and Stefano Di Biase and Hamed Mirzaei and Mario G. Mirisola and Patra Childress and Lingyun Ji and Susan Groshen and Fabio Penna and Patrizio R Odetti and Laura Perin and Peter S. Conti and Yuji Ikeno and Brian Kennedy and Pinchas Cohen and Todd E Morgan and Tanya B Dorff and Valter D Longo},
  journal={Cell metabolism},
  year={2015},
  volume={22 1},
  pages={86-99}
}
Prolonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, 4 days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems, an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
77 Extracted Citations
75 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 77 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 75 references

Performance, and Healthspan, Cell Metabolism

  • M. Z. Ratajczak, E. K. Zuba-Surma, M. Wysoczynski, J. Ratajczak, M. Kucia
  • Proc. Natl. Acad. Sci. USA
  • 2015

opmental origin, and biological significance

  • K. Richetin, C. Leclerc, +4 authors C. Rampon
  • Exp. Hematol
  • 2015
2 Excerpts

Similar Papers

Loading similar papers…