A Pericyte Origin of Spinal Cord Scar Tissue

@article{Gritz2011APO,
  title={A Pericyte Origin of Spinal Cord Scar Tissue},
  author={C. G{\"o}ritz and D. O. Dias and N. Tomilin and M. Barbacid and O. Shupliakov and J. Fris{\'e}n},
  journal={Science},
  year={2011},
  volume={333},
  pages={238 - 242}
}
Scars formed in response to damage to the central nervous system show unexpected complexity. There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in… Expand
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