A Pericyte Origin of Spinal Cord Scar Tissue

  title={A Pericyte Origin of Spinal Cord Scar Tissue},
  author={Christian G{\"o}ritz and David O. Dias and Nikolay V. Tomilin and Mariano Barbacid and Oleg Shupliakov and Jonas Fris{\'e}n},
  pages={238 - 242}
Scars formed in response to damage to the central nervous system show unexpected complexity. There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in… 

Starting the scar: a primary role for pericytes?

The authors tracked a population of pericytes, type A pericytic cells, in a mouse model of spinal cord injury and found that descendants of these pericycletes were required for scar formation.

Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury

It is demonstrated that perivascular collagen1α1 cells are the main source of the cellular composition of the fibrotic scar after contusive spinal cord injury in which the dura remains intact.

Fibrotic scarring following lesions to the central nervous system.

  • D. O. DiasC. Göritz
  • Biology, Medicine
    Matrix biology : journal of the International Society for Matrix Biology
  • 2018

The soft mechanical signature of glial scars in the central nervous system

Describing spatiotemporal changes of the elastic stiffness of the injured rat neocortex and spinal cord at 1.5 and three weeks post-injury using atomic force microscopy may help to understand why mammalian neurons do not regenerate after injury.

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

Pericyte-derived fibrosis is uncovered as a conserved mechanism that may be explored as a therapeutic target to improve recovery after central nervous system lesions.

The glial scar in spinal cord injury and repair

The role of glial scar formation in the regulation of axonal regeneration and the cascades of neuro-inflammation is discussed, with special focus on the potential cellular origin of scar-forming cells and the molecular mechanisms underlying glia scar formation after SCI.

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

The Fibrotic Scar in Neurological Disorders

It is believed that the fibrotic scar represents a major barrier to CNS regeneration, and targeting of fibrosis may prove to be a valuable therapeutic strategy for neurological disorders such as stroke, spinal cord injury and multiple sclerosis.

Regeneration: Not everything is scary about a glial scar

It is demonstrated that limiting the formation of the scar actually attenuates axon re-growth, and it is suggested that astrocyte scarring promotes — rather than prevents — CNS axon regeneration post-injury.



Regeneration beyond the glial scar

Chondroitin and keratan sulphate proteoglycans are among the main inhibitory extracellular matrix molecules that are produced by reactive astrocytes in the glial scar, and they are believed to play a crucial part in regeneration failure.

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells

Using genetic fate mapping, it is shown that close to all in vitro neural stem cell potential in the adult spinal cord resides within the population of ependymal cells lining the central canal.

The bright side of the glial scar in CNS repair

Following CNS injury, in an apparently counterintuitive response, scar tissue formation inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar-modulating treatments have

Long‐term changes in the molecular composition of the glial scar and progressive increase of serotoninergic fibre sprouting after hemisection of the mouse spinal cord

The scarring process occurring after adult central nervous system injury and the subsequent increase in the expression of certain extracellular matrix molecules are known to contribute to the failure

Pericyte migration from the vascular wall in response to traumatic brain injury.

This work examined, at the ultrastructural level, microvascular pericyte responses in a well-defined model of traumatic brain injury in the rat, and found migrated pericytes appeared viable and remained in a perivascular location in the adjacent neuropil.

Fibroblast differentiation in wound healing and fibrosis.

Overcoming inhibition in the damaged spinal cord.

Inhibition by several inhibitory molecules on oligodendrocytes, and by chondroitin sulphate proteoglycans and semaphorins in the glial scar discourages regeneration of axons in the injured spinal

The CNS microvascular pericyte: pericyte-astrocyte crosstalk in the regulation of tissue survival

Evidence for cell-to-cell crosstalk between pericytes and astrocytes during development and in adult brain is considered.