A Pericyte Origin of Spinal Cord Scar Tissue

@article{Gritz2011APO,
  title={A Pericyte Origin of Spinal Cord Scar Tissue},
  author={Christian G{\"o}ritz and David O. Dias and Nikolay V. Tomilin and Mariano Barbacid and Oleg Shupliakov and Jonas Fris{\'e}n},
  journal={Science},
  year={2011},
  volume={333},
  pages={238 - 242}
}
Scars formed in response to damage to the central nervous system show unexpected complexity. There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in… 

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Describing spatiotemporal changes of the elastic stiffness of the injured rat neocortex and spinal cord at 1.5 and three weeks post-injury using atomic force microscopy may help to understand why mammalian neurons do not regenerate after injury.

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

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Regeneration: Not everything is scary about a glial scar

It is demonstrated that limiting the formation of the scar actually attenuates axon re-growth, and it is suggested that astrocyte scarring promotes — rather than prevents — CNS axon regeneration post-injury.
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