A Perfect Storm: Fetal Inflammation and the Developing Immune System

  title={A Perfect Storm: Fetal Inflammation and the Developing Immune System},
  author={Dajana Sabic and Joyce M. Koenig},
  journal={Pediatric research},
  pages={319 - 326}
Histologic chorioamnionitis is an inflammatory disorder of the placenta that commonly precedes preterm delivery. Preterm birth related to chorioamnionitis and fetal inflammation has been associated with a risk for serious inflammatory complications in infancy. In addition, preterm infants exposed to chorioamnionitis may be more susceptible to infection in the neonatal intensive care unit and possibly later in life. A significant body of work has established an association between… Expand
Preterm Birth Is Associated With Immune Dysregulation Which Persists in Infants Exposed to Histologic Chorioamnionitis
Introduction Preterm infants are at increased risk of exposure to histologic chorioamnionitis (HCA) when compared to term-born controls, and this is associated with several neonatal morbiditiesExpand
Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero
Prenatal inflammation improved lung function at the expense of stem/progenitor alterations that potentially disrupt normal lung development, thereby predisposing to adverse postnatal outcomes, and interventions, which promote function or repair of endogenous stem cells in the lungs, hold great promise. Expand
Potential Prenatal Origins of Necrotizing Enterocolitis.
The evidence behind the prenatal risk factors for necrotizing enterocolitis is reviewed, and it is discussed how these risk factors may elucidate the pathogenesis of necrotizedEnterocolitis and provide insight into prevention and treatment. Expand
Mechanisms of brain injury in newborn infants associated with the fetal inflammatory response syndrome.
The fetal inflammatory response syndrome (FIRS) is characterized by umbilical cord inflammation and elevated fetal pro-inflammatory cytokines. Surviving neonates, especially very preterm infants,Expand
Large Platelet and Endothelial Extracellular Vesicles in Cord Blood of Preterm Newborns: Correlation with the Presence of Hemolysis
Different biomarkers are investigated to detect the causes of severe complications in preterm infants. Extracellular vesicles (EVs) are recognized as an important part of cell-to-cell communication,Expand


Fetal immune response to chorioamnionitis.
The focus is on the immune changes in multiple fetal organs and the pathogenesis of chorioamnionitis-induced injury in different fetal compartments and the relevant developmental context for the immune system. Expand
Inflammatory response in acute chorioamnionitis.
  • R. Redline
  • Medicine
  • Seminars in fetal & neonatal medicine
  • 2012
The issues addressed are the nature and origin of the eliciting antigen, mode of spread to the placenta, general characteristics of placental immunity, and a specific characterization of the spectrum of pathologic lesions observed in placentas with membrane infection. Expand
Diagnosis and management of clinical chorioamnionitis.
Clinical research into better methods for diagnosing, treating, and preventing chorioamnionitis is likely to have a substantial impact on short and long-term outcomes in the neonate. Expand
Intrauterine inflammation, infection, or both (Triple I): A new concept for chorioamnionitis.
The current literature on chorioamnionitis is reviewed, the concept of Triple I is introduced, as well as recommendations for assessment and management of pregnant women and their newborns with a diagnosis of triple I are introduced. Expand
Fetal Inflammatory Response and Brain Injury in the Preterm Newborn
Preterm birth can be caused by intrauterine infection and maternal/fetal inflammatory responses. Maternal inflammation (chorioamnionitis) is often followed by a systemic fetal inflammatory responseExpand
Chorioamnionitis, neuroinflammation, and injury: timing is key in the preterm ovine fetus
Increased understanding of the spatiotemporal pathophysiological changes in the preterm brain following intra-amniotic inflammation which may aid development of new interventions or implement interventions more effectively to prevent perinatal brain damage is provided. Expand
Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis
Exposure to chorioamnionitis exposure, in particular to funisitis, lead to enhanced Th17-like responses that persist for 4 wk after birth, which is similar to what is seen in infants with mild BPD. Expand
Augmented Th17-Type Immune Responses in Preterm Neonates Exposed to Histologic Chorioamnionitis
It is speculated that a Th17 bias may potentiate the inflammatory responses and related morbidity observed in preterm neonates whose immune systems have been “primed” by HCA exposure. Expand
Chorioamnionitis, IL‐17A, and fetal origins of neurologic disease
The role of IL‐17A in fetal and maternal proinflammatory responses that lead to fetal brain injury and neurologic sequelae, including cerebral palsy are detailed. Expand
Augmentation of fetal granulopoiesis with chorioamnionitis during the second trimester of gestation.
Under normal conditions fetal liver granulopoiesis is at a very low level within the sinusoids, but an early and substantial increase can be seen most easily in this location during infection; chorioamnionitis can be diagnosed from the fetal liver alone. Expand