A Perfect Message RNA Surveillance and Nonsense-Mediated Decay

@article{Hentze1999APM,
  title={A Perfect Message RNA Surveillance and Nonsense-Mediated Decay},
  author={Matthias W. Hentze and Andreas E. Kulozik},
  journal={Cell},
  year={1999},
  volume={96},
  pages={307-310}
}
the disposal of nonfunctional by-products of normal The robustness of biological systems depends on the RNA processing. function of proofreading mechanisms against operating NMD—An Enigma in RNA Metabolism errors. Studies in yeast and of human genetic disorders NMD has captured much attention as one of the most have lead the way to a conserved surveillance mechaenigmatic processes in RNA metabolism. Basically, a cell nism that identifies faulty open reading frames (ORFs) must discriminate the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 381 CITATIONS, ESTIMATED 59% COVERAGE

Nonsense-mediated decay as the molecular cause for autosomal recessive bestrophinopathy in two unrelated families.

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Most Human Proteins Made in Both Nucleus and Cytoplasm Turn Over within Minutes

VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

A nonsense mutation in MLH1 causes exon skipping in three unrelated HNPCC families.

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2020

CITATION STATISTICS

  • 22 Highly Influenced Citations

  • Averaged 12 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-2 OF 2 REFERENCES

EMBOcomplex commits the mRNA to the NMD pathway ( Fig - J

  • M. J. Ruiz-Echevarria, C. I. Gonzalez, S. W. Peltz
  • 1998
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Maquat , 1997 ) , as seen in yeast .

  • J. Zhang, X. Sun, Y. Qian, J. P. LaDuca, L. E. Maquat
  • Furthermore , the exis - Mol . Cell . Biol .