A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli.

Abstract

Increasing antibacterial resistance presents a major challenge in antibiotic discovery. One attractive target in Gram-negative bacteria is the unique asymmetric outer membrane (OM), which acts as a permeability barrier that protects the cell from external stresses, such as the presence of antibiotics. We describe a novel β-hairpin macrocyclic peptide JB-95… (More)
DOI: 10.1074/jbc.M115.691725

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Cite this paper

@article{Urfer2016APA, title={A Peptidomimetic Antibiotic Targets Outer Membrane Proteins and Disrupts Selectively the Outer Membrane in Escherichia coli.}, author={Matthias Urfer and Jasmina Bogdanovic and Fabio Lo Monte and Kerstin M{\"{o}hle and Katja Zerbe and Ulrich Omasits and Christian H. Ahrens and Gabriella Pessi and Leo Eberl and John A. Robinson}, journal={The Journal of biological chemistry}, year={2016}, volume={291 4}, pages={1921-32} }