A Peptidic Unconjugated GRP78/BiP Ligand Modulates the Unfolded Protein Response and Induces Prostate Cancer Cell Death

@article{Maddalo2012APU,
  title={A Peptidic Unconjugated GRP78/BiP Ligand Modulates the Unfolded Protein Response and Induces Prostate Cancer Cell Death},
  author={Danilo Maddalo and Antje J. Neeb and Katja Jehle and Katja Schmitz and Claudia Muhle-Goll and Liubov Shatkina and Tamara Vanessa Walther and Anja Bruchmann and Srinivasa Murthy Gopal and Wolfgang Wenzel and Anne S. Ulrich and Andrew C B Cato},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
The molecular chaperone GRP78/BiP is a key regulator of protein folding in the endoplasmic reticulum, and it plays a pivotal role in cancer cell survival and chemoresistance. Inhibition of its function has therefore been an important strategy for inhibiting tumor cell growth in cancer therapy. Previous efforts to achieve this goal have used peptides that bind to GRP78/BiP conjugated to pro-drugs or cell-death-inducing sequences. Here, we describe a peptide that induces prostate tumor cell death… Expand
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