A Peptide Inhibitor Reveals an Extended Conformation of Transglutaminase 2

Abstract

Transglutaminase 2 (TG2) is a ubiquitous enzyme which catalyzes the crosslinking of proteins via formation of epsilon-(gamma-glutamyl) lysine bonds as well as deamidation of glutamine residues to glutamate in suitable substrates. The activity of Transglutaminase 2 has been implicated in the pathology of several diseases including Celiac Disease and diseases… (More)

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