A Peptide Found in Schizophrenia and Autism Causes Behavioral Changes in Rats

@article{Sun1999APF,
  title={A Peptide Found in Schizophrenia and Autism Causes Behavioral Changes in Rats},
  author={Zhong Sheng Sun and J. Robert Cade},
  journal={Autism},
  year={1999},
  volume={3},
  pages={85 - 95}
}
In a previous study we showed that β-casomorphin-7 (β-CM7) is taken up by brain regions relevant to schizophrenia and autism. The present experiment was designed to find whether β-CM7 has any behavioral or analgesic effects in rats. About 65 seconds after treatment with different doses of β-CM7, rats became restless and ran violently, with teeth chattering and with rapid respiration. Seven minutes later, the rats became inactive with less walking, distancing themselves from the other rat in the… 

Figures and Tables from this paper

Behavioral effects of food-derived opioid-like peptides in rodents: Implications for schizophrenia?
TLDR
Food-derived peptides can affect rodent behavior, but more studies of GDs using diverse behavioral batteries are warranted, as these peptides may affect human behavior.
The possibility and probability of a gut-to-brain connection in autism.
  • K. Reichelt, A. Knivsberg
  • Chemistry, Medicine
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
  • 2009
TLDR
It is shown that urine peptide increase is found in autism, and that some of these peptides have a dietary origin, and an effect of diet on excreted compounds and behavior has been found.
Autism and Schizophrenia: Intestinal Disorders
TLDR
The data provide support for the proposal that many patients with schizophrenia or autism suffer due to absorption of exorphins formed in the intestine from incomplete digestion of gluten and casein.
Can the Pathophysiology of Autism be Explained by the Nature of the Discovered Urine Peptides?
TLDR
The data presented form the basis of an autism model, where it is suggested that exorphins and serotonin uptake modulators are key mediators for the development of autism.
The impact of milk caseins on behavioural development in rats : exploring the role of the gut brain axis
TLDR
The findings suggest casein exposure beyond weaning age results in neurochemical and emotional impairments via a potential microbiome-gut-brain axis mechanism and indicates that prolonged breastfeeding periods may cause mood disorders in humans and highlight the need for more comprehensive guidelines regarding an appropriate weaned age.
Etiology of autism and camel milk as therapy
The etiology of many autistic cases is based on a primary autoimmune disease, affecting an intestinal enzyme responsible for the formation of amino acids from the milk protein casein. Instead, the
GFCF Diet in ASD
There is a rising interest in the use of dietary interventions to ameliorate prevalent brain diseases, including Autism Spectrum Disorder (ASD). Nowadays, the existence of communication between gut
Peptides and Exorphins in the Autism Spectrum
Problem: Some researchers have not found the opioids in urine of autistic children. We have therefore looked at this problem again. Method: Mass spectrometry and fragmentation mass spectrometry
Prolonged exposure to milk caseins in early postnatal life increases depressive-like behaviour
TLDR
It is hypothesised that prolonged exposure to milk caseins, beyond the normal age of weaning, may influence the development of DOPr, resulting in alterations to mood, and down regulation of OTR in casein rich animals is identified.
Can the pathophysiology of autism be explained by the nature of the discovered urine peptides and dietary antigens?
TLDR
The urine analysis for exorphins for routine use in blood and cerebrospinal fluid is developed to validate the new method in autism for both urine, blood and CSF and to pick out generally active peptides in any one disorder.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 31 REFERENCES
β-Casomorphin Induces Fos-Like Immunoreactivity in Discrete Brain Regions Relevant to Schizophrenia and Autism
The induction of Fos-like immunoreactivity (FLI) was used to determine the brain localization affected by b-casomorphin-7 (b-CM7). Peripheral administration of human b-CM7 at different doses (5, 10
Biologically active peptide-containing fractions in schizophrenia and childhood autism.
TLDR
It is demonstrated that, in schizophrenia and autism (in well defined clinical cases), the patterns of peptides and associated proteins from urinary samples differ considerably from each other and from normal controls.
A peptide-containing fraction in the urine of schizophrenic patients which stimulates opiate receptors and inhibits dopamine uptake
TLDR
It was concluded that schizophrenic patients excrete in the urine peptides or peptide-like factors which have strong opiate receptor stimulating effects, and which also result in dopaminergic stimulation.
A peptide-containing fraction of plasma from schizophrenic patients which binds to opiate receptors and induces hyper-reactivity in rats
TLDR
An in vitro opiate receptor binding test showed that fraction II from schizophrenic patients inhibited [3H]naloxone binding, and there was evidence that fraction III was also active.
Elevated opioid activity in sera of chronic schizophrenics.
TLDR
It is speculated that new appearance or the accumulation in the sera of several, and partly at least, unknown peptides and glycopeptides disclosing opioid activity might be characteristic of schizophrenia.
Increased concentration of α- and γ-endorphin in post mortem hypothalamic tissue of schizophrenic patients
TLDR
Results suggest a deviant metabolism of β-endorphin in the brain of schizophrenic patients, and whether this phenomenon is related to the psychopathology, or is a consequence of ante mortem farmacotherapy, remains to be established.
Opioid activities of beta-casomorphins.
TLDR
Four β-casomorphins probably represent μ-type opiate receptor agonists in view of the fact that the GPI, MVD and RVD are populated predominantly by μ-, δ- and e-receptors, respectively.
Neuroleptic activity of the neuropeptide β-LPH62–77 ([Des-Tyr1]γ-endorphin; DTγE)
In contrast to β-endorphin, α-endorphin, β-LPH61–69 and Met-enkephalin which delay extinction of pole-jumping avoidance behavior (De Wied et al., 1978), γ-endorphin given either subcutaneously (30
Effects of methionine-enkephalin and morphine on spontaneous locomotor activity: Antagonism by naloxone
  • H. Bhargava
  • Medicine, Chemistry
    Pharmacology Biochemistry and Behavior
  • 1978
TLDR
It is concluded that morphine and MEK produce differential effects on mouse spontaneous motor activity with respect to time and dose and that naloxone can inhibit the effects of MEK more effectively than that of morphine on motor activity.
CSF and plasma beta-casomorphin-like opioid peptides in postpartum psychosis.
TLDR
Certain cases of postpartum psychosis are associated with the occurrence in plasma and CSF of unique opioid peptides probably related to bovine beta-casomorphin, the authors conclude.
...
1
2
3
4
...