A Peptide Based Dual-Labeled Agent Targeted to Interleukin 11 Receptor Alpha-Chain for Molecular Imaging

@inproceedings{Lin2009APB,
  title={A Peptide Based Dual-Labeled Agent Targeted to Interleukin 11 Receptor Alpha-Chain for Molecular Imaging},
  author={Y-H. Lin and G-C. Liu and T-S. Jaw and Y-T. Kuo and C-Y. S. Chen and Y-M. Wang},
  year={2009}
}
This study describes the synthesis and biologic evaluation of a IL11 peptide targeted dual-labeled imaging agent as a potential probe for detecting human breast cancer with magnetic resonance imaging (MRI) and optical imaging. The IL11 peptide substrate was synthesized and conjugated with the TTDA chelating moiety and cy5.5 (Gd-NB-TTDA-IL11-cy5.5) via solid-phase peptide synthesis, purified by reversed-phase HPLC and identified by mass. The T1 relaxivity of Gd-NB-TTDA-IL11 was 5.48 mM s at 37… CONTINUE READING