A Peculiar Mutation Spectrum Emerging from Young Peruvian Patients with Hepatocellular Carcinoma

@article{Marchio2014APM,
  title={A Peculiar Mutation Spectrum Emerging from Young Peruvian Patients with Hepatocellular Carcinoma},
  author={A. Marchio and S. Bertani and T. Rojas Rojas and F. Doimi and B. Terris and E. Deharo and A. Dejean and E. Ruiz and P. Pineau},
  journal={PLoS ONE},
  year={2014},
  volume={9}
}
Hepatocellular carcinoma usually afflicts individuals in their later years following longstanding liver disease. In Peru, hepatocellular carcinoma exists in a unique clinical presentation, which affects patients around age 25 with a normal, healthy liver. In order to deepen our understanding of the molecular processes ongoing in Peruvian liver tumors, mutation spectrum analysis was carried out on hepatocellular carcinomas from 80 Peruvian patients. Sequencing analysis focused on nine genes… Expand
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