A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish.

@article{Prasad2014APR,
  title={A Pd-based regioselective strategy to indole-1,2-fused 8- and 9-membered rings: their evaluation as potential scaffolds for apoptosis in zebrafish.},
  author={Bagineni Prasad and Bachchewal Sreenivas and Araka Sushma and Swapna Yellanki and Raghavender Medisetti and Pushkar Kulkarni and Manojit Pal},
  journal={Organic & biomolecular chemistry},
  year={2014},
  volume={12 18},
  pages={2864-8}
}
A strategy based on Pd-mediated ring closure of 1,2-disubstituted indoles containing an unactivated olefin leading to indole-1,2-fused 8- and 9-membered rings has been developed for the identification of new and potential scaffolds for apoptosis. A large number of fused indole derivatives containing an endocyclic double bond were synthesized using this robust methodology. A representative compound showed promising apoptotic properties in zebrafish embryos. 

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