A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.

@article{Brendolan2005APG,
  title={A Pbx1-dependent genetic and transcriptional network regulates spleen ontogeny.},
  author={Andrea Brendolan and Elisabetta Ferretti and Valentina Salsi and Kelvin A. Moses and Susan E Quaggin and Francesco Blasi and Michael L. Cleary and Licia Selleri},
  journal={Development},
  year={2005},
  volume={132 13},
  pages={3113-26}
}
The genetic control of cell fate specification, morphogenesis and expansion of the spleen, a crucial lymphoid organ, is poorly understood. Recent studies of mutant mice implicate various transcription factors in spleen development, but the hierarchical relationships between these factors have not been explored. In this report, we establish a genetic network that regulates spleen ontogeny, by analyzing asplenic mice mutant for the transcription factors Pbx1, Hox11 (Tlx1), Nkx3.2 (Bapx1) and Pod1… CONTINUE READING

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