A Pathogen Type III Effector with a Novel E3 Ubiquitin Ligase Architecture

  title={A Pathogen Type III Effector with a Novel E3 Ubiquitin Ligase Architecture},
  author={A. Singer and S. Schulze and T. Skarina and X. Xu and Hong Cui and Lennart Eschen-Lippold and Monique Egler and T. Srikumar and B. Raught and J. Lee and D. Scheel and A. Savchenko and U. Bonas},
  journal={PLoS Pathogens},
  • A. Singer, S. Schulze, +10 authors U. Bonas
  • Published 2013
  • Biology, Medicine
  • PLoS Pathogens
  • Type III effectors are virulence factors of Gram-negative bacterial pathogens delivered directly into host cells by the type III secretion nanomachine where they manipulate host cell processes such as the innate immunity and gene expression. Here, we show that the novel type III effector XopL from the model plant pathogen Xanthomonas campestris pv. vesicatoria exhibits E3 ubiquitin ligase activity in vitro and in planta, induces plant cell death and subverts plant immunity. E3 ligase activity… CONTINUE READING
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