BACKGROUND The aim of this study was to verify a path model of job stress using Thai-JCQ. METHODS The population of this cross-sectional study was 800 immigrant employees in the central region of Thailand in 2015 by stratified random sampling. Instruments used both the applied and standard questionnaires. Job stress was measured using Thai-JCQ dealt with psychosocial work factors. A path model of job stress using Thai-JCQ was verified using M-plus. RESULTS Variables could explain the job stress change by 22.2%. Working conditions, job securities, workloads had direct effect on job stress while, workloads had indirect effect as well. Wages did not have any significance. CONCLUSION The results of this study have implications for public health under occupational health research and practice by making public health and occupational health professionals aware of the importance a comprehensive approach to job stress prevention in the vulnerable population.