A Parylene Self-Locking Cuff Electrode for Peripheral Nerve Stimulation and Recording

  title={A Parylene Self-Locking Cuff Electrode for Peripheral Nerve Stimulation and Recording},
  author={Huaiqiang Yu and Wenjie Xiong and Hongze Zhang and Wei Wang and Zhihong Li},
  journal={Journal of Microelectromechanical Systems},
The cuff electrode provides a stable interface with the peripheral nerve, which has been widely utilized in both basic research and clinical practice over the past few decades. In this paper, we present a microfabricated, parylene-based self-locking cuff electrode. The cuff diameter can be adjusted to accommodate the nerve properly during implantation. This type of cuff electrodes is easy to implant and the cuff was made of the thin, flexible, and biocompatible parylene substrate. Moreover, the… 
Parylene-Based Cuff Electrode With Integrated Microfluidics for Peripheral Nerve Recording, Stimulation, and Drug Delivery
A novel Parylene C-based peripheral nerve interface that combines both electrodes and microfluidic channels in an adjustable cuff has the potential to enhance implant-tissue integration in vivo and provide reliable chronic performance not available in the existing extraneural or intraneural interfaces.
Stretchable gold nanowire-based cuff electrodes for low-voltage peripheral nerve stimulation
The developed stretchable cuff electrode combines favourable mechanical properties and good electrode performance with inert and stable materials, making it ideal for low power supply applications within bioelectronic medicine.
Flexible 3D carbon nanotubes cuff electrodes as a peripheral nerve interface
The experimental results demonstrate the proposed CNT electrode has a better performance than Pt electrode in nerve stimulation and indicates that flexible 3D CNTs cuff electrode provides an excellent platform for functional electrical stimulation.
Recording nerve signals in canine sciatic nerves with a flexible penetrating microelectrode array
The presented results demonstrate the viability of the developed FPMA device in the peripheral nerves of medium-sized animals, thereby bringing us a step closer to human applications.
Hook and loop microfastener: Flexible microelectrodes tied to a nerve
  • Y. Seki, S. Yamagiwa, T. Kawano
  • Biology, Engineering
    2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)
  • 2017
A highly-flexible and -biocompatible parylene-based microelectrode array with a hook and loop microfastener, which realizes the electrode stably tied to a nerve (∼1 mm in diameter) is proposed.
Implantable neurotechnologies: a review of micro- and nanoelectrodes for neural recording
Current and future considerations in electrode design, including the use of inorganic nanostructures and biologically inspired or biocomapatible materials are discussed, along with an overview of the applications of flexible materials and transistor transduction schemes.
Flexible and Highly Biocompatible Nanofiber-Based Electrodes for Neural Surface Interfacing.
An NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility is demonstrated and can record stable neural signals for extended periods of time.
Flexible Epineural Strip Electrode for Recording in Fine Nerves
Flexible epineural strip electrodes (FLESE) are demonstrated for recording from small nerves for less damage in a nerve and optimal recording quality, and new concept of FLESEs could play an important role in electroceuticals in near future.
Soft implantable microelectrodes for future medicine: prosthetics, neural signal recording and neuromodulation.
An overview of recent advances in soft-material-based implantable electrodes for medical applications, categorized according to their implantation site and material composition is provided.


Polyimide cuff electrodes for peripheral nerve stimulation
A multielectrode array for intrafascicular recording and stimulation in sciatic nerve of cats
Cuff electrodes for chronic stimulation and recording of peripheral nerve activity
Chronic measurement of the stimulation selectivity of the flat interface nerve electrode
The flat interface nerve electrode (FINE) is an attempt to improve the stimulation selectivity of extraneural electrodes. By reshaping peripheral nerves into elliptical cylinders, central fibers are
A transverse intrafascicular multichannel electrode (TIME) to interface with the peripheral nerve.
A cable-tie-type parylene cuff electrode for peripheral nerve interfaces
We have designed, fabricated and characterized a cable-tie-type parylene cuff electrode for peripheral nerve interfaces, whose diameter is adjustable to accommodate the nerve properly during
Functionally selective peripheral nerve stimulation with a flat interface nerve electrode
  • D. Tyler, D. Durand
  • Biology
    IEEE Transactions on Neural Systems and Rehabilitation Engineering
  • 2002
The flat interface nerve electrode (FINE) reshapes the nerve into a flat geometry to increase the surface area and move central axon populations close to the surface.
A simple cuff electrode for nerve recording and stimulation in acute experiments on small animals
A spiral nerve cuff electrode for peripheral nerve stimulation
The authors hypothesize that unlike traditional cuffs, the spiral cuff potentially can be implanted safely when sized to fit peripheral nerves snugly and results of a preliminary experiment in which snug spiral cuffs were implanted on feline peripheral nerve support the prediction that they may be safe.