A Parsimony Approach to Analysis of Human Segmental Duplications

@article{Kahn2009APA,
  title={A Parsimony Approach to Analysis of Human Segmental Duplications},
  author={Crystal L. Kahn and Benjamin J. Raphael},
  journal={Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing},
  year={2009},
  pages={126-37}
}
Segmental duplications are abundant in the human genome, but their evolutionary history is not well-understood. The mystery surrounding them is due in part to their complex organization; many segmental duplications are mosaic patterns of smaller repeated segments, or duplicons. A two-step model of duplication has been proposed to explain these mosaic patterns. In this model, duplicons are copied and aggregated into primary duplication blocks that subsequently seed secondary duplications. Here… CONTINUE READING
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