A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.

@article{Winzer2012APS,
  title={A Papaver somniferum 10-gene cluster for synthesis of the anticancer alkaloid noscapine.},
  author={Thilo Winzer and Valeria E Gazda and Zhesi He and Filip Kaminski and Marcelo Kern and Tony R Larson and Yi Li and Fergus Meade and Roxana I. Teodor and Fabi{\'a}n E. Vaistij and Carol Walker and Tim A. Bowser and Ian A Graham},
  journal={Science},
  year={2012},
  volume={336 6089},
  pages={1704-8}
}
Noscapine is an antitumor alkaloid from opium poppy that binds tubulin, arrests metaphase, and induces apoptosis in dividing human cells. Elucidation of the biosynthetic pathway will enable improvement in the commercial production of noscapine and related bioactive molecules. Transcriptomic analysis revealed the exclusive expression of 10 genes encoding… CONTINUE READING